Product Data Sheet
CN-716 dihydrochloride
Catalog No. A50736
CN-716 dihydrochloride is a reversible covalent inhibitor targeting the NS2B·NS3 protease of flaviviruses, demonstrating significant antiviral activity. This compound effectively impedes the replication of dengue virus (DENV2), West Nile virus (WNV), and Zika virus (ZIKV), with IC50 values of 0.066 μM, 0.11 μM, and 0.25 μM, respectively. Additionally, CN-716 dihydrochloride exhibits Ki values of 0.051 μM, 0.082 μM, and 0.04 μM against the same proteases. It serves as a valuable tool for investigating the infection mechanisms associated with dengue fever, West Nile fever, and Zika virus infection.
Chemical Information
| Catalog Num | A50736 |
|---|---|
| M. Wt | 527.25 |
| Formula | C22H33BCl2N6O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2077164-48-6 |
| Synonyms | |
| SMILES | NCC(C=C1)=CC=C1C[C@H](NC(C2=CC=CC=C2)=O)C(N[C@H](B(O)O)CCCNC(N)=N)=O.Cl.Cl |
Biological Activity
| Description | CN-716 dihydrochloride is a reversible covalent inhibitor targeting the NS2B·NS3 protease of flaviviruses, demonstrating significant antiviral activity. This compound effectively impedes the replication of dengue virus (DENV2), West Nile virus (WNV), and Zika virus (ZIKV), with IC50 values of 0.066 μM, 0.11 μM, and 0.25 μM, respectively. Additionally, CN-716 dihydrochloride exhibits Ki values of 0.051 μM, 0.082 μM, and 0.04 μM against the same proteases. It serves as a valuable tool for investigating the infection mechanisms associated with dengue fever, West Nile fever, and Zika virus infection. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
