Product Data Sheet
VK-2019
Catalog No. A50742
VK-2019 is an orally bioavailable selective inhibitor targeting the Epstein-Barr virus nuclear antigen 1 (EBNA1). By disrupting the protein-DNA interface, VK-2019 interferes with the recruitment of viral DNA replication machinery, effectively blocking EBV replication in latently infected cells. This compound has been shown to reduce the copy number and gene expression of Epstein-Barr virus, decrease EBER-positive cells, and exhibit significant antiviral, immunomodulatory, and antiproliferative effects. In vivo studies demonstrate that VK-2019 inhibits tumor growth in EBV-dependent xenograft models, making it a valuable tool for research in advanced nasopharyngeal carcinoma and various EBV-associated malignancies.
Chemical Information
| Catalog Num | A50742 |
|---|---|
| M. Wt | 451.51 |
| Formula | C29H25NO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2044520-06-9 |
| Synonyms | |
| SMILES | O=C(C1=C(C2=CC3=C(C=CN3)C=C2)C(C#CC4=CC=C(COC5CCOCC5)C=C4)=CC=C1)O |
Biological Activity
| Description | VK-2019 is an orally bioavailable selective inhibitor targeting the Epstein-Barr virus nuclear antigen 1 (EBNA1). By disrupting the protein-DNA interface, VK-2019 interferes with the recruitment of viral DNA replication machinery, effectively blocking EBV replication in latently infected cells. This compound has been shown to reduce the copy number and gene expression of Epstein-Barr virus, decrease EBER-positive cells, and exhibit significant antiviral, immunomodulatory, and antiproliferative effects. In vivo studies demonstrate that VK-2019 inhibits tumor growth in EBV-dependent xenograft models, making it a valuable tool for research in advanced nasopharyngeal carcinoma and various EBV-associated malignancies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
