Product Data Sheet
Glycolithocholic acid 3-sulfate disodium
Catalog No. A51301
Glycolithocholic acid 3-sulfate disodium functions as a GPR39 agonist, exhibiting EC50 values of 47.9 and 66.8 μM in the absence of Zn2+, and 8 and 8.7 μM in the presence of Zn2+ in M39-20 and hGPR39-2 cell lines, respectively. This compound activates GPR39 receptors to promote intracellular calcium signaling without relying on Zn2+ binding sites H17 and H19. Additionally, it demonstrates the ability to inhibit HIV-1 replication in vitro. Glycolithocholic acid 3-sulfate disodium is a valuable tool for investigating HIV infection and gallbladder disease mechanisms.
Chemical Information
| Catalog Num | A51301 |
|---|---|
| M. Wt | 557.65 |
| Formula | C26H41NNa2O7S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 64936-82-9 |
| Synonyms | Glycolithocholate sulfate disodium; Sulfolithocholylglycine disodium; SLCG disodium |
| SMILES | C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NCC(O[Na])=O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@@H](CC4)OS(=O)(O[Na])=O)([H])CC3)C |
Biological Activity
| Description | Glycolithocholic acid 3-sulfate disodium functions as a GPR39 agonist, exhibiting EC50 values of 47.9 and 66.8 μM in the absence of Zn2+, and 8 and 8.7 μM in the presence of Zn2+ in M39-20 and hGPR39-2 cell lines, respectively. This compound activates GPR39 receptors to promote intracellular calcium signaling without relying on Zn2+ binding sites H17 and H19. Additionally, it demonstrates the ability to inhibit HIV-1 replication in vitro. Glycolithocholic acid 3-sulfate disodium is a valuable tool for investigating HIV infection and gallbladder disease mechanisms. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
