Product Data Sheet
BDM-2
Catalog No. A51328
BDM-2 is a potent allosteric inhibitor of HIV-1 integrase, specifically targeting the IN-LEDGF interaction. With an IC50 of 47 nM, it exhibits significant anti-retroviral activity and an AC50 for IN multimerization activation of 20 nM. BDM-2 effectively disrupts the binding between the integrase catalytic core domain and the LEDGF/p75 integrase binding domain, with an IC50 of 0.15 μM. This compound demonstrates a high degree of selectivity and a favorable cytotoxicity profile, making it a valuable tool for HIV research.
Chemical Information
| Catalog Num | A51328 |
|---|---|
| M. Wt | 394.50 |
| Formula | C25H30O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1643876-33-8 |
| Synonyms | |
| SMILES | CC(C)(C)O[C@@H](C1=C(C2=CC=C(OCCC3)C3=C2)C(C4CC4)=CC=C1C)C(O)=O |
Biological Activity
| Description | BDM-2 is a potent allosteric inhibitor of HIV-1 integrase, specifically targeting the IN-LEDGF interaction. With an IC50 of 47 nM, it exhibits significant anti-retroviral activity and an AC50 for IN multimerization activation of 20 nM. BDM-2 effectively disrupts the binding between the integrase catalytic core domain and the LEDGF/p75 integrase binding domain, with an IC50 of 0.15 μM. This compound demonstrates a high degree of selectivity and a favorable cytotoxicity profile, making it a valuable tool for HIV research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
