Product Data Sheet
IMB-301
Catalog No. A51364
IMB-301 is a selective inhibitor of HIV-1 replication that targets the interaction between human APOBEC3G (hA3G) and viral protein Vif. By disrupting this interaction, IMB-301 prevents Vif-mediated degradation of hA3G, a crucial restriction factor in HIV-1 replication. With an IC50 value of 8.63 µM, IMB-301 effectively inhibits HIV-1 replication in H9 cells, making it a valuable tool for studying HIV-1 biology and developing antiviral strategies.
Chemical Information
| Catalog Num | A51364 |
|---|---|
| M. Wt | 379.26 |
| Formula | C19H17Cl2FN2O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 64009-84-3 |
| Synonyms | |
| SMILES | FC1=CC=C(OCCC(C2=CC=C(Cl)C=C2Cl)CN3C=CN=C3)C=C1 |
Biological Activity
| Description | IMB-301 is a selective inhibitor of HIV-1 replication that targets the interaction between human APOBEC3G (hA3G) and viral protein Vif. By disrupting this interaction, IMB-301 prevents Vif-mediated degradation of hA3G, a crucial restriction factor in HIV-1 replication. With an IC50 value of 8.63 µM, IMB-301 effectively inhibits HIV-1 replication in H9 cells, making it a valuable tool for studying HIV-1 biology and developing antiviral strategies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
