Product Data Sheet
AzddMeC
Catalog No. A51366
AzddMeC is a potent, selective nucleoside analogue that functions as an inhibitor of HIV-1 reverse transcriptase, effectively blocking HIV-1 replication. The compound demonstrates strong antiviral activity, with EC50 values of 9 nM in HIV-1-infected human peripheral blood mononuclear cells and 6 nM in HIV-1-infected human macrophages. In addition to its antiviral properties, AzddMeC serves as a versatile click chemistry reagent, containing an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne- and DBCO- or BCN-containing molecules, respectively, making it a valuable tool in chemical biology research.
Chemical Information
| Catalog Num | A51366 |
|---|---|
| M. Wt | 266.26 |
| Formula | C10H14N6O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 87190-79-2 |
| Synonyms | CS-92 |
| SMILES | O=C1N([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C=C(C)C(N)=N1 |
Biological Activity
| Description | AzddMeC is a potent, selective nucleoside analogue that functions as an inhibitor of HIV-1 reverse transcriptase, effectively blocking HIV-1 replication. The compound demonstrates strong antiviral activity, with EC50 values of 9 nM in HIV-1-infected human peripheral blood mononuclear cells and 6 nM in HIV-1-infected human macrophages. In addition to its antiviral properties, AzddMeC serves as a versatile click chemistry reagent, containing an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne- and DBCO- or BCN-containing molecules, respectively, making it a valuable tool in chemical biology research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
