Product Data Sheet
GSK3739936
Catalog No. A51384
GSK3739936 is a potent allosteric inhibitor of HIV-1 integrase, exhibiting an IC50 value of 11.1 nM and an EC50 of 1.7 nM. In addition to its inhibitory effects, GSK3739936 demonstrates weak inhibition of cytochrome P450 enzymes (IC50 > 24.3 μM). This compound also showcases favorable pharmacokinetic properties in preclinical models, characterized by rapid absorption, low to moderate clearance rates, and excellent oral bioavailability, making it a promising candidate for further research in HIV therapeutics.
Chemical Information
| Catalog Num | A51384 |
|---|---|
| M. Wt | 562.71 |
| Formula | C34H43FN2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1803444-21-4 |
| Synonyms | BMS-986180 |
| SMILES | CC1=NC(C)=C(C(N2CCC(C)(CC2)C)=C1[C@@H](C(O)=O)OC(C)(C)C)C3=CC=C(C=C3)OCCC4=CC=C(C=C4)F |
Biological Activity
| Description | GSK3739936 is a potent allosteric inhibitor of HIV-1 integrase, exhibiting an IC50 value of 11.1 nM and an EC50 of 1.7 nM. In addition to its inhibitory effects, GSK3739936 demonstrates weak inhibition of cytochrome P450 enzymes (IC50 > 24.3 μM). This compound also showcases favorable pharmacokinetic properties in preclinical models, characterized by rapid absorption, low to moderate clearance rates, and excellent oral bioavailability, making it a promising candidate for further research in HIV therapeutics. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
