Product Data Sheet
HIV-1 inhibitor-51
Catalog No. A51396
HIV-1 inhibitor-51 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets the reverse transcriptase enzyme of HIV-1, demonstrating potent antiviral activity against both wild-type and mutant strains. It exhibits a high binding affinity with a KD of 2.50 μM and shows significant inhibitory potency with an IC50 of 0.03 μM against wild-type HIV-1 reverse transcriptase. Additionally, HIV-1 inhibitor-51 has effective EC50 values ranging from 2.22 to 53.3 nM against a range of clinically relevant mutant strains, making it a valuable tool for research in HIV-1 drug resistance and antiviral drug development.
Chemical Information
| Catalog Num | A51396 |
|---|---|
| M. Wt | 463.89 |
| Formula | C24H19ClFN5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2834087-82-8 |
| Synonyms | |
| SMILES | FC(C=C1NC2=NC(OC3=C(C=C(C=C3C)/C=C/C#N)C)=C4C(COC4)=N2)=C(C=C1)C#N.Cl |
Biological Activity
| Description | HIV-1 inhibitor-51 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets the reverse transcriptase enzyme of HIV-1, demonstrating potent antiviral activity against both wild-type and mutant strains. It exhibits a high binding affinity with a KD of 2.50 μM and shows significant inhibitory potency with an IC50 of 0.03 μM against wild-type HIV-1 reverse transcriptase. Additionally, HIV-1 inhibitor-51 has effective EC50 values ranging from 2.22 to 53.3 nM against a range of clinically relevant mutant strains, making it a valuable tool for research in HIV-1 drug resistance and antiviral drug development. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
