Product Data Sheet
Oltipraz-d3
Catalog No. A51472
Oltipraz-d3 is a deuterium-labeled derivative of Oltipraz, primarily targeting hypoxia-inducible factor 1-alpha (HIF-1α). It demonstrates inhibitory effects on HIF-1α activation in a time-dependent manner, fully suppressing its induction at concentrations of 10 μM or greater, with an IC50 value of 10 μM. Additionally, Oltipraz acts as a potent activator of Nrf2, making it a valuable reagent for studies investigating cellular responses to hypoxic conditions and oxidative stress.
Chemical Information
| Catalog Num | A51472 |
|---|---|
| M. Wt | 229.36 |
| Formula | C8H3D3N2S3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2012598-51-3 |
| Synonyms | RP 35972-d3; NSC 347901-d3 |
| SMILES | S=C1SSC(C2=NC=CN=C2)=C1C([2H])([2H])[2H] |
Biological Activity
| Description | Oltipraz-d3 is a deuterium-labeled derivative of Oltipraz, primarily targeting hypoxia-inducible factor 1-alpha (HIF-1α). It demonstrates inhibitory effects on HIF-1α activation in a time-dependent manner, fully suppressing its induction at concentrations of 10 μM or greater, with an IC50 value of 10 μM. Additionally, Oltipraz acts as a potent activator of Nrf2, making it a valuable reagent for studies investigating cellular responses to hypoxic conditions and oxidative stress. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
