Product Data Sheet
Lopinavir-d7
Catalog No. A51477
Lopinavir-d7 is a deuterated derivative of Lopinavir, a selective peptidomimetic inhibitor targeting the HIV-1 protease. It demonstrates potent activity, with Ki values ranging from 1.3 to 3.6 pM against both wild-type and mutant HIV proteases, effectively preventing HIV-1 maturation and subsequent infectivity. Additionally, Lopinavir has been identified as an inhibitor of SARS-CoV 3CLpro, showcasing an IC50 of 14.2 μM, making it valuable for research in virology and antiviral drug development.
Chemical Information
| Catalog Num | A51477 |
|---|---|
| M. Wt | 635.84 |
| Formula | C37H41D7N4O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1432060-78-0 |
| Synonyms | ABT-378-d7 |
| SMILES | CC1=C(OCC(N[C@@H](CC2=CC=CC=C2)[C@@H](O)C[C@H](CC3=CC=CC=C3)NC([C@H](C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])N4C(NCCC4)=O)=O)=O)C(C)=CC=C1 |
Biological Activity
| Description | Lopinavir-d7 is a deuterated derivative of Lopinavir, a selective peptidomimetic inhibitor targeting the HIV-1 protease. It demonstrates potent activity, with Ki values ranging from 1.3 to 3.6 pM against both wild-type and mutant HIV proteases, effectively preventing HIV-1 maturation and subsequent infectivity. Additionally, Lopinavir has been identified as an inhibitor of SARS-CoV 3CLpro, showcasing an IC50 of 14.2 μM, making it valuable for research in virology and antiviral drug development. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
