Product Data Sheet
U-104489
Catalog No. A51515
U-104489 is a potent inhibitor of HIV-1, targeting the reverse transcriptase (RT) enzyme. It demonstrates Ki values of 0.13 μM against the wild-type p66/p51 variant (G190), and 0.12 μM against the G190A variant, while exhibiting significantly reduced activity (Ki > 100 μM) against the G190E variant. This compound is valuable for research applications aimed at understanding HIV-1 resistance mechanisms and developing effective antiretroviral therapies.
Chemical Information
| Catalog Num | A51515 |
|---|---|
| M. Wt | 512.67 |
| Formula | C26H36N6O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 177577-60-5 |
| Synonyms | |
| SMILES | O=C(N1CCC(CC1)N(CC)C2=NC=CC=C2NC(C)(C)C)C3=CC4=C(N3)C=CC(NS(=O)(C)=O)=C4 |
Biological Activity
| Description | U-104489 is a potent inhibitor of HIV-1, targeting the reverse transcriptase (RT) enzyme. It demonstrates Ki values of 0.13 μM against the wild-type p66/p51 variant (G190), and 0.12 μM against the G190A variant, while exhibiting significantly reduced activity (Ki > 100 μM) against the G190E variant. This compound is valuable for research applications aimed at understanding HIV-1 resistance mechanisms and developing effective antiretroviral therapies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
