Product Data Sheet
Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium
Catalog No. A51609
Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium is a potent HIV inhibitor that demonstrates significantly prolonged half-life values compared to tenofovir in human liver microsomes. This compound exhibits robust anti-HIV activity in vitro and shows enhanced pharmacokinetic properties in vivo. Additionally, it serves as a click chemistry reagent featuring an alkyne group, which allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating various research applications in medicinal chemistry and drug development.
Chemical Information
| Catalog Num | A51609 |
|---|---|
| M. Wt | 626.84 |
| Formula | C29H55N6O5PSi |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2611373-74-9 |
| Synonyms | |
| SMILES | C[Si](C)(C)C#CCCCCCCCCCCCCOCCCOP(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)([O-])=O.[NH4+] |
Biological Activity
| Description | Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium is a potent HIV inhibitor that demonstrates significantly prolonged half-life values compared to tenofovir in human liver microsomes. This compound exhibits robust anti-HIV activity in vitro and shows enhanced pharmacokinetic properties in vivo. Additionally, it serves as a click chemistry reagent featuring an alkyne group, which allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating various research applications in medicinal chemistry and drug development. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
