Product Data Sheet
Rp-dGTPαS
Catalog No. A51631
Rp-dGTPαS is a nucleotide substrate for SAMHD1, which plays a critical role in regulating cellular dNTP pools and inhibiting viral replication, particularly in CD4+ myeloid cells and resting T cells. The enzyme SAMHD1, in its tetrameric form, catalyzes the hydrolysis of Rp-dGTPαS into 2'-deoxynucleosides and triphosphates, thereby affecting nucleic acid metabolism and viral clearance. This compound is valuable for studies related to HIV-1 biology and dNTP regulation in various cellular contexts.
Chemical Information
| Catalog Num | A51631 |
|---|---|
| M. Wt | 523.25 |
| Formula | C10H16N5O12P3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 80902-29-0 |
| Synonyms | |
| SMILES | OP(OP(O[P@@](OC[C@@H]1[C@@H](O)C[C@H](N(C=N2)C(NC(N)=N3)=C2C3=O)O1)(S)=O)(O)=O)(O)=O |
Biological Activity
| Description | Rp-dGTPαS is a nucleotide substrate for SAMHD1, which plays a critical role in regulating cellular dNTP pools and inhibiting viral replication, particularly in CD4+ myeloid cells and resting T cells. The enzyme SAMHD1, in its tetrameric form, catalyzes the hydrolysis of Rp-dGTPαS into 2'-deoxynucleosides and triphosphates, thereby affecting nucleic acid metabolism and viral clearance. This compound is valuable for studies related to HIV-1 biology and dNTP regulation in various cellular contexts. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
