Product Data Sheet
Kuwanon L
Catalog No. A51705
Kuwanon L is an inhibitor of HIV-1 integrase that effectively disrupts the interaction between HIV-1 integrase and LEDGF/p75, demonstrating IC50 values of 42 µM for LEDGF-dependent and 34 µM for LEDGF-independent integrase activity. With an IC50 of 22 µM for the integrase-LEDGF/p75 interaction, Kuwanon L also inhibits HIV-1 replication in immune cells. This compound is valuable for research focused on HIV-1 infection and the mechanisms underlying viral integration.
Chemical Information
| Catalog Num | A51705 |
|---|---|
| M. Wt | 626.61 |
| Formula | C35H30O11 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 88524-65-6 |
| Synonyms | |
| SMILES | O=C(C1=C(C=C(C=C1)O)O)[C@@H]2[C@@H](C3=C(C([C@H]4OC5=CC(O)=CC(O)=C5C(C4)=O)=CC=C3O)O)C=C(C[C@H]2C6=C(C=C(C=C6)O)O)C |
Biological Activity
| Description | Kuwanon L is an inhibitor of HIV-1 integrase that effectively disrupts the interaction between HIV-1 integrase and LEDGF/p75, demonstrating IC50 values of 42 µM for LEDGF-dependent and 34 µM for LEDGF-independent integrase activity. With an IC50 of 22 µM for the integrase-LEDGF/p75 interaction, Kuwanon L also inhibits HIV-1 replication in immune cells. This compound is valuable for research focused on HIV-1 infection and the mechanisms underlying viral integration. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
