Product Data Sheet
Dolutegravir-d5
Catalog No. A51733
Dolutegravir-d5 is a deuterium-labeled analog of Dolutegravir, a potent inhibitor of HIV-1 integrase strand transfer. It demonstrates exceptional antiviral activity with an IC50 value of 2.7 nM against HIV-1 integrase and an IC50 of 0.51 nM for suppressing viral replication in peripheral blood mononuclear cells. Additionally, Dolutegravir maintains strong efficacy against key HIV-1 variants, including Y143R, N155H, and G140S/Q148H mutants, with EC50 values ranging from 3.6 to 5.8 nM. This stable isotope is valuable for pharmacokinetic studies and metabolic research in HIV treatment.
Chemical Information
| Catalog Num | A51733 |
|---|---|
| M. Wt | 424.41 |
| Formula | C20H14D5F2N3O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2249814-82-0 |
| Synonyms | S/GSK1349572-d5 |
| SMILES | FC1=C([2H])C(F)=C(C([2H])=C1[2H])C([2H])([2H])NC(C2=CN(C3=C(C2=O)O)C[C@@]([H])(N4C3=O)OCC[C@H]4C)=O |
Biological Activity
| Description | Dolutegravir-d5 is a deuterium-labeled analog of Dolutegravir, a potent inhibitor of HIV-1 integrase strand transfer. It demonstrates exceptional antiviral activity with an IC50 value of 2.7 nM against HIV-1 integrase and an IC50 of 0.51 nM for suppressing viral replication in peripheral blood mononuclear cells. Additionally, Dolutegravir maintains strong efficacy against key HIV-1 variants, including Y143R, N155H, and G140S/Q148H mutants, with EC50 values ranging from 3.6 to 5.8 nM. This stable isotope is valuable for pharmacokinetic studies and metabolic research in HIV treatment. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
