Product Data Sheet
Lopinavir-d8
Catalog No. A51740
Lopinavir-d8 is a deuterated form of the potent HIV-1 protease inhibitor Lopinavir, functioning primarily by inhibiting the enzyme's activity, which is crucial for viral maturation. With an affinity (Kis) ranging from 1.3 to 3.6 pM against both wild-type and mutant strains of HIV protease, Lopinavir-d8 effectively blocks HIV-1 infectivity. Additionally, it serves as an inhibitor of SARS-CoV 3CLpro, exhibiting an IC50 value of 14.2 μM, making it valuable for research on viral proteases and potential therapeutic applications in retroviral and coronavirus research.
Chemical Information
| Catalog Num | A51740 |
|---|---|
| M. Wt | 636.85 |
| Formula | C37H40D8N4O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1224729-35-4 |
| Synonyms | |
| SMILES | CC(C=CC=C1C)=C1OCC(N[C@@H](CC2=CC=CC=C2)[C@@H](O)C[C@H](CC3=CC=CC=C3)NC([C@](N4C(NCCC4)=O)([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=O)=O |
Biological Activity
| Description | Lopinavir-d8 is a deuterated form of the potent HIV-1 protease inhibitor Lopinavir, functioning primarily by inhibiting the enzyme's activity, which is crucial for viral maturation. With an affinity (Kis) ranging from 1.3 to 3.6 pM against both wild-type and mutant strains of HIV protease, Lopinavir-d8 effectively blocks HIV-1 infectivity. Additionally, it serves as an inhibitor of SARS-CoV 3CLpro, exhibiting an IC50 value of 14.2 μM, making it valuable for research on viral proteases and potential therapeutic applications in retroviral and coronavirus research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
