Product Data Sheet
VNT-101
Catalog No. A52007
VNT-101 is an orally active inhibitor of influenza A virus (IAV) that targets the nucleoprotein (NP) and disrupts NP-NP protein-protein interactions, leading to the destabilization of the viral ribonucleoprotein complex. This compound demonstrates potent antiviral activity across various IAV subtypes, with EC50 values ranging from 4-5 nM in cellular cytopathic effect assays, 4-8 nM in neuraminidase assays, and 21-45 nM in ribonucleoprotein assays. Additionally, VNT-101 shows significant in vivo antiviral efficacy in mice infected with lethal H1N1 virus, making it a valuable tool for studying influenza A infection and potential therapeutic interventions.
Chemical Information
| Catalog Num | A52007 |
|---|---|
| M. Wt | 456.41 |
| Formula | C21H23F3N2O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2894060-67-2 |
| Synonyms | |
| SMILES | COC[C@]1(COC[C@H](O1)COC2=CC=C(C(C=C3C(N)=O)=C(C(F)(F)F)NC3=O)C=C2)C |
Biological Activity
| Description | VNT-101 is an orally active inhibitor of influenza A virus (IAV) that targets the nucleoprotein (NP) and disrupts NP-NP protein-protein interactions, leading to the destabilization of the viral ribonucleoprotein complex. This compound demonstrates potent antiviral activity across various IAV subtypes, with EC50 values ranging from 4-5 nM in cellular cytopathic effect assays, 4-8 nM in neuraminidase assays, and 21-45 nM in ribonucleoprotein assays. Additionally, VNT-101 shows significant in vivo antiviral efficacy in mice infected with lethal H1N1 virus, making it a valuable tool for studying influenza A infection and potential therapeutic interventions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
