Product Data Sheet
PAN endonuclease-IN-1
Catalog No. A52056
PAN endonuclease-IN-1 is a potent inhibitor of PAN endonuclease, showing Kd values of 277 μM, 384 μM, and 328 μM for wild-type, I38T, and E23K variants, respectively. Targeting the RNA-dependent RNA polymerase acidic N-terminal endonuclease, this compound plays a critical role in disrupting influenza viral replication. It is a valuable tool for studying antiviral strategies and the effects of PAN endonuclease inhibition on influenza virus biology.
Chemical Information
| Catalog Num | A52056 |
|---|---|
| M. Wt | 367.24 |
| Formula | C14H8F3N5O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2378640-67-4 |
| Synonyms | |
| SMILES | O=C(C(NC(C1=C(C(F)(F)F)C=C(C2=NN=NN2)C=C1)=C3)=C(O)C3=O)O |
Biological Activity
| Description | PAN endonuclease-IN-1 is a potent inhibitor of PAN endonuclease, showing Kd values of 277 μM, 384 μM, and 328 μM for wild-type, I38T, and E23K variants, respectively. Targeting the RNA-dependent RNA polymerase acidic N-terminal endonuclease, this compound plays a critical role in disrupting influenza viral replication. It is a valuable tool for studying antiviral strategies and the effects of PAN endonuclease inhibition on influenza virus biology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
