Product Data Sheet
Purfalcamine
Catalog No. A52266
Purfalcamine is a selective inhibitor of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1), exhibiting an IC50 of 17 nM and an EC50 of 230 nM. It demonstrates potent antimalarial activity by inducing developmental arrest of malaria parasites at the schizont stage. This compound serves as a valuable tool for investigating the role of PfCDPK1 in malaria pathogenesis and development, offering insights into potential therapeutic strategies against malaria.
Chemical Information
| Catalog Num | A52266 |
|---|---|
| M. Wt | 528.62 |
| Formula | C29H33FN8O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1038620-68-6 |
| Synonyms | |
| SMILES | O=C(C1=CC=C(NC2=C3N=CN(C4=CC=CC(F)=C4)C3=NC(N[C@H]5CC[C@H](N)CC5)=N2)C=C1)N6CCCCC6 |
Biological Activity
| Description | Purfalcamine is a selective inhibitor of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1), exhibiting an IC50 of 17 nM and an EC50 of 230 nM. It demonstrates potent antimalarial activity by inducing developmental arrest of malaria parasites at the schizont stage. This compound serves as a valuable tool for investigating the role of PfCDPK1 in malaria pathogenesis and development, offering insights into potential therapeutic strategies against malaria. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
