Product Data Sheet
Epoxyazadiradione
Catalog No. A52345
Epoxyazadiradione is a limonoid derived from the fruits of the neem tree (Azadirachta indica) that targets macrophage migration inhibitory factor (MIF). It exhibits non-competitive inhibition of the tautomerase activity of both human MIF (huMIF) and MIF from malaria parasites, specifically Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF), with a Ki value ranging from 2.11 to 5.23 μM. This compound demonstrates potential in modulating proinflammatory responses associated with MIF in both human and malaria contexts, making it a valuable tool for research into anti-parasitic strategies and inflammatory diseases.
Chemical Information
| Catalog Num | A52345 |
|---|---|
| M. Wt | 466.57 |
| Formula | C28H34O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 18385-59-6 |
| Synonyms | |
| SMILES | C[C@]12[C@]34[C@]([C@@](C5=COC=C5)([H])C([C@@]3([H])O4)=O)(CC[C@]1([H])[C@@]6([C@@](C(C)(C(C=C6)=O)C)([H])C[C@H]2OC(C)=O)C)C |
Biological Activity
| Description | Epoxyazadiradione is a limonoid derived from the fruits of the neem tree (Azadirachta indica) that targets macrophage migration inhibitory factor (MIF). It exhibits non-competitive inhibition of the tautomerase activity of both human MIF (huMIF) and MIF from malaria parasites, specifically Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF), with a Ki value ranging from 2.11 to 5.23 μM. This compound demonstrates potential in modulating proinflammatory responses associated with MIF in both human and malaria contexts, making it a valuable tool for research into anti-parasitic strategies and inflammatory diseases. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
