Product Data Sheet
DNDI-VL-2098
Catalog No. A52565
DNDI-VL-2098 is an orally active antileishmanial agent targeting Leishmania parasites. It demonstrates high permeability and in vitro metabolic stability while selectively inhibiting CYP2C19, with an IC50 of 0.47 μM, without affecting other major CYP enzymes at concentrations up to 12.5 μM. This compound exhibits favorable pharmacokinetic properties across various animal models, including mice, hamsters, rats, and dogs, with moderate to high plasma protein binding. DNDI-VL-2098 is a valuable reagent for the study of visceral leishmaniasis.
Chemical Information
| Catalog Num | A52565 |
|---|---|
| M. Wt | 359.26 |
| Formula | C14H12F3N3O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 681492-17-1 |
| Synonyms | |
| SMILES | FC(F)(F)OC(C=C1)=CC=C1OC[C@@]2(OC3=NC([N+]([O-])=O)=CN3C2)C |
Biological Activity
| Description | DNDI-VL-2098 is an orally active antileishmanial agent targeting Leishmania parasites. It demonstrates high permeability and in vitro metabolic stability while selectively inhibiting CYP2C19, with an IC50 of 0.47 μM, without affecting other major CYP enzymes at concentrations up to 12.5 μM. This compound exhibits favorable pharmacokinetic properties across various animal models, including mice, hamsters, rats, and dogs, with moderate to high plasma protein binding. DNDI-VL-2098 is a valuable reagent for the study of visceral leishmaniasis. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
