Product Data Sheet
Dieugenol
Catalog No. A53058
Dieugenol is a neolignan with notable antiprotozoal activity, specifically targeting parasitic infections. It exhibits inhibitory effects on T. cruzi, exhibiting IC50 values of 15.1 μM against amastigotes and 11.5 μM against trypomastigotes, while demonstrating antioxidative properties by scavenging superoxide anions and inhibiting thiobarbituric acid reactive substances (TBARS) formation. Although Dieugenol disrupts the plasma membrane integrity of T. cruzi trypomastigotes at a concentration of 15 μM, it shows cytotoxicity to NCTC L-929 fibroblasts with a CC50 value of 58.2 μM, indicating its potential for further investigation in parasitic disease research.
Chemical Information
| Catalog Num | A53058 |
|---|---|
| M. Wt | 326.39 |
| Formula | C20H22O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 4433-08-3 |
| Synonyms | Bis-eugenol; Dehydrodieugenol |
| SMILES | OC1=C(OC)C=C(CC=C)C=C1C2=CC(CC=C)=CC(OC)=C2O |
Biological Activity
| Description | Dieugenol is a neolignan with notable antiprotozoal activity, specifically targeting parasitic infections. It exhibits inhibitory effects on T. cruzi, exhibiting IC50 values of 15.1 μM against amastigotes and 11.5 μM against trypomastigotes, while demonstrating antioxidative properties by scavenging superoxide anions and inhibiting thiobarbituric acid reactive substances (TBARS) formation. Although Dieugenol disrupts the plasma membrane integrity of T. cruzi trypomastigotes at a concentration of 15 μM, it shows cytotoxicity to NCTC L-929 fibroblasts with a CC50 value of 58.2 μM, indicating its potential for further investigation in parasitic disease research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
