Product Data Sheet
Tetromycin B
Catalog No. A53072
Tetromycin B is a potent cysteine protease inhibitor, demonstrating Ki values of 0.62, 1.42, 32.5, and 1.59 μM against rhodesain, falcipain-2, cathepsin L, and cathepsin B, respectively. This compound effectively inhibits the growth of Trypanosoma brucei in vitro with an IC50 of 30.87 μM. Additionally, Tetromycin B exhibits cytotoxic effects on HEK293T kidney cells and J774.1 macrophages, with IC50 values of 71.77 μM and 20.2 μM, respectively, highlighting its potential utility in research applications targeting parasitic infections.
Chemical Information
| Catalog Num | A53072 |
|---|---|
| M. Wt | 534.73 |
| Formula | C34H46O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 180027-84-3 |
| Synonyms | |
| SMILES | CC1=C[C@]2([C@@]([H])([C@H](CC[C@@H]2O)C)[C@@](C)([C@@]1(/C(C)=C/CC/C(C)=C/[C@]3([C@]4(C[C@H](C(C)=C3)C)OC5=O)C)[H])C(C5=C4O)=O)[H] |
Biological Activity
| Description | Tetromycin B is a potent cysteine protease inhibitor, demonstrating Ki values of 0.62, 1.42, 32.5, and 1.59 μM against rhodesain, falcipain-2, cathepsin L, and cathepsin B, respectively. This compound effectively inhibits the growth of Trypanosoma brucei in vitro with an IC50 of 30.87 μM. Additionally, Tetromycin B exhibits cytotoxic effects on HEK293T kidney cells and J774.1 macrophages, with IC50 values of 71.77 μM and 20.2 μM, respectively, highlighting its potential utility in research applications targeting parasitic infections. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
