Product Data Sheet
Pomotrelvir
Catalog No. A53220
Pomotrelvir is a selective, competitive, orally active covalent inhibitor of the SARS-CoV-2 main protease (Mpro), exhibiting an IC50 of 24 nM against wild-type SARS-CoV-2 Mpro. By inhibiting viral polyprotein processing, it effectively disrupts viral replication. Pomotrelvir demonstrates broad antiviral activity against various SARS-CoV-2 variants, including Omicron, and shows an additive effect when co-administered with nucleoside analogs targeting viral RNA synthesis. It is primarily utilized in the research and development of antiviral therapeutics for COVID-19 caused by SARS-CoV-2 and its variants.
Chemical Information
| Catalog Num | A53220 |
|---|---|
| M. Wt | 455.94 |
| Formula | C23H26ClN5O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2713437-86-4 |
| Synonyms | PBI-0451 |
| SMILES | ClC1=C2C(C=C(N2)C(N[C@H](C(N[C@H](C#N)C[C@H]3C(NCCC3)=O)=O)CC4CC4)=O)=CC=C1 |
Biological Activity
| Description | Pomotrelvir is a selective, competitive, orally active covalent inhibitor of the SARS-CoV-2 main protease (Mpro), exhibiting an IC50 of 24 nM against wild-type SARS-CoV-2 Mpro. By inhibiting viral polyprotein processing, it effectively disrupts viral replication. Pomotrelvir demonstrates broad antiviral activity against various SARS-CoV-2 variants, including Omicron, and shows an additive effect when co-administered with nucleoside analogs targeting viral RNA synthesis. It is primarily utilized in the research and development of antiviral therapeutics for COVID-19 caused by SARS-CoV-2 and its variants. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
