Product Data Sheet
SARS-CoV-IN-6
Catalog No. A53318
SARS-CoV-IN-6 is a selective inhibitor of the RNA-dependent RNA polymerase (RdRp) of both SARS-CoV-1 and SARS-CoV-2, featuring an IC50 of 7.8 μM against SARS-CoV-2 RdRp. This compound effectively mitigates cytopathic effects in cells infected with SARS-CoV-1 and SARS-CoV-2 replicon-based single-round infectious particles (SRIPs). Additionally, it inhibits the expression of the SARS-CoV N protein, showing EC50 values of 0.12 µM for SARS-CoV-1 SRIPs and 1.47 µM for SARS-CoV-2 SRIPs. SARS-CoV-IN-6 is valuable for research focused on the antiviral mechanisms targeting coronavirus replication.
Chemical Information
| Catalog Num | A53318 |
|---|---|
| M. Wt | 447.53 |
| Formula | C25H29N5O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2244671-47-2 |
| Synonyms | |
| SMILES | CN1C(N(C)C=C(CNC2=CC=C3N(C[C@H]4C[C@@H]3CN(CC5=CC=CC=C5)C4)C2=O)C1=O)=O |
Biological Activity
| Description | SARS-CoV-IN-6 is a selective inhibitor of the RNA-dependent RNA polymerase (RdRp) of both SARS-CoV-1 and SARS-CoV-2, featuring an IC50 of 7.8 μM against SARS-CoV-2 RdRp. This compound effectively mitigates cytopathic effects in cells infected with SARS-CoV-1 and SARS-CoV-2 replicon-based single-round infectious particles (SRIPs). Additionally, it inhibits the expression of the SARS-CoV N protein, showing EC50 values of 0.12 µM for SARS-CoV-1 SRIPs and 1.47 µM for SARS-CoV-2 SRIPs. SARS-CoV-IN-6 is valuable for research focused on the antiviral mechanisms targeting coronavirus replication. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
