Product Data Sheet
NZ-804
Catalog No. A53366
NZ-804 is a potent inhibitor of the SARS-CoV-2 main protease (Mpro), exhibiting an IC50 of 8.9 nM. This compound effectively reduces SARS-CoV-2 replication in HeLa-hACE2 cells, with an EC50 of 14 nM. NZ-804 demonstrates broad-spectrum antiviral activity against various coronaviruses and has been shown to significantly diminish viral replication in mouse and hamster models, making it a valuable tool for research into COVID-19 and related viral infections.
Chemical Information
| Catalog Num | A53366 |
|---|---|
| M. Wt | 469.55 |
| Formula | C27H23N3O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2858658-44-1 |
| Synonyms | |
| SMILES | O=C(N1CC/C(CC1)=C2C3=C(CS(=O)(C4=C/2C=CC=C4)=O)C=CC=C3)C5=CN=CC6=C5NC=C6 |
Biological Activity
| Description | NZ-804 is a potent inhibitor of the SARS-CoV-2 main protease (Mpro), exhibiting an IC50 of 8.9 nM. This compound effectively reduces SARS-CoV-2 replication in HeLa-hACE2 cells, with an EC50 of 14 nM. NZ-804 demonstrates broad-spectrum antiviral activity against various coronaviruses and has been shown to significantly diminish viral replication in mouse and hamster models, making it a valuable tool for research into COVID-19 and related viral infections. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
