Product Data Sheet
SIMR3030
Catalog No. A53429
SIMR3030 is a highly effective inhibitor of the SARS-CoV-2 PLpro enzyme, exhibiting an IC50 value of 0.0399 µg/mL. This compound demonstrates significant antiviral activity, reducing the expression levels of SARS-CoV spike, ORF1b, IFN-α, and IL-6 mRNA. Additionally, SIMR3030 has shown a favorable safety profile in murine models, making it a valuable reagent for research into COVID-19 therapeutics and fundamental coronavirus biology.
Chemical Information
| Catalog Num | A53429 |
|---|---|
| M. Wt | 427.54 |
| Formula | C27H29N3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2708270-99-7 |
| Synonyms | |
| SMILES | [H][C@@]12CC[C@]3(CC4=C(NC5=C4C=C(C=C5)OC)C[C@]3(N1CCC6=C2NC7=CC=CC=C76)[H])OC |
Biological Activity
| Description | SIMR3030 is a highly effective inhibitor of the SARS-CoV-2 PLpro enzyme, exhibiting an IC50 value of 0.0399 µg/mL. This compound demonstrates significant antiviral activity, reducing the expression levels of SARS-CoV spike, ORF1b, IFN-α, and IL-6 mRNA. Additionally, SIMR3030 has shown a favorable safety profile in murine models, making it a valuable reagent for research into COVID-19 therapeutics and fundamental coronavirus biology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
