Product Data Sheet
VPC285785
Catalog No. A53453
VPC285785 is a potent inhibitor of the SARS-CoV-2 main protease, exhibiting an IC50 of 0.8 μM and a Kd of 2.7 μM. This compound effectively disrupts the processing of viral polyprotein precursors, which is crucial for viral replication. In studies with MHV-infected mice, VPC285785 significantly lowered viral loads in the liver, brain, and spleen. This reagent is valuable for research focused on coronavirus infections and therapeutic development.
Chemical Information
| Catalog Num | A53453 |
|---|---|
| M. Wt | 469.48 |
| Formula | C24H25F2N5O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2759276-10-1 |
| Synonyms | |
| SMILES | FC1=CC(F)=C(C=C(C(N2C[C@H](C3(C)C)[C@H]3[C@H]2C(N[C@H](C#N)C[C@@H]4CCNC4=O)=O)=O)N5)C5=C1 |
Biological Activity
| Description | VPC285785 is a potent inhibitor of the SARS-CoV-2 main protease, exhibiting an IC50 of 0.8 μM and a Kd of 2.7 μM. This compound effectively disrupts the processing of viral polyprotein precursors, which is crucial for viral replication. In studies with MHV-infected mice, VPC285785 significantly lowered viral loads in the liver, brain, and spleen. This reagent is valuable for research focused on coronavirus infections and therapeutic development. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
