Product Data Sheet
M2 ion channel blocker-2
Catalog No. A53486
M2 Ion Channel Blocker-2 is a selective inhibitor of M2 ion channels, effectively targeting both wild-type and mutant variants (L27F and V27A). This compound exhibits significant antiviral activity against HCoV-229E, with an EC50 value of 4.7 μM in cytopathic effect assays, while showing no antiviral effects against influenza A virus. Additionally, M2 Ion Channel Blocker-2 demonstrates negligible inhibition of hERG and key cytochrome P450 enzymes (CYP1A2, CYP2C19, and CYP3A4), making it a useful tool for research in virology and ion channel modulation.
Chemical Information
| Catalog Num | A53486 |
|---|---|
| M. Wt | 205.34 |
| Formula | C14H23N |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2260797-32-6 |
| Synonyms | |
| SMILES | NC12C[C@]3(C)C4(C)CC1CC4(C)C3(C)C2 |
Biological Activity
| Description | M2 Ion Channel Blocker-2 is a selective inhibitor of M2 ion channels, effectively targeting both wild-type and mutant variants (L27F and V27A). This compound exhibits significant antiviral activity against HCoV-229E, with an EC50 value of 4.7 μM in cytopathic effect assays, while showing no antiviral effects against influenza A virus. Additionally, M2 Ion Channel Blocker-2 demonstrates negligible inhibition of hERG and key cytochrome P450 enzymes (CYP1A2, CYP2C19, and CYP3A4), making it a useful tool for research in virology and ion channel modulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
