Product Data Sheet
TKB272
Catalog No. A53490
TKB272 is a selective antiviral agent targeting the main protease (Mpro) of SARS-CoV-2. It effectively inhibits the infection and replication of various SARS-CoV-2 strains, including Omicron variants, with an IC50 of 0.7 µM and an EC50 as low as 2.6 nM in cellular assays. Additionally, TKB272 demonstrates a high safety profile with a CC50 of 98 µM, indicating minimal cytotoxicity. Its ability to significantly reduce replication in transgenic mouse models highlights its potential as a valuable tool for SARS-CoV-2 research.
Chemical Information
| Catalog Num | A53490 |
|---|---|
| M. Wt | 653.69 |
| Formula | C30H35F4N5O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2892688-18-3 |
| Synonyms | |
| SMILES | O=C(N[C@H](C(N1C[C@H](C2(C)C)[C@H]2[C@H]1C(N[C@H](C(C3=NC(C=C(F)C=C4)=C4S3)=O)C[C@@H]5CCNC5=O)=O)=O)C(C)(C)C)C(F)(F)F |
Biological Activity
| Description | TKB272 is a selective antiviral agent targeting the main protease (Mpro) of SARS-CoV-2. It effectively inhibits the infection and replication of various SARS-CoV-2 strains, including Omicron variants, with an IC50 of 0.7 µM and an EC50 as low as 2.6 nM in cellular assays. Additionally, TKB272 demonstrates a high safety profile with a CC50 of 98 µM, indicating minimal cytotoxicity. Its ability to significantly reduce replication in transgenic mouse models highlights its potential as a valuable tool for SARS-CoV-2 research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
