Product Data Sheet
PhAc-ALGP-Dox
Catalog No. A53644
PhAc-ALGP-Dox is a peptide-drug conjugate designed for targeted anticancer therapy. This prodrug demonstrates significant cytotoxic activity against triple-negative breast cancer (TNBC) cell lines, with IC50 values ranging from 311 nM to 34.25 μM for E0771, MDA-MB-231, and MDA-MB-468, as well as exhibiting effects on colorectal carcinoma (CrC) cells (LS 174T) and normal epithelial cells. Its unique mechanism allows for selective delivery of doxorubicin, making it a valuable tool for research applications focused on improving chemotherapy efficacy and reducing off-target effects in cancer treatment.
Chemical Information
| Catalog Num | A53644 |
|---|---|
| M. Wt | 1003.94 |
| Formula | C45H58N5O19P |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1616592-31-4 |
| Synonyms | |
| SMILES | OC=1C2=C([C@@H](O[C@H]3C[C@H](NC(=O)[C@H]4N(C(CNC([C@@H](NC([C@@H](NC(CP(=O)(O)O)=O)C)=O)CC(C)C)=O)=O)CCC4)[C@H](O)[C@H](C)O3)C[C@@](C(CO)=O)(O)C2)C(O)=C5C1C(=O)C=6C(C5=O)=C(OC)C=CC6 |
Biological Activity
| Description | PhAc-ALGP-Dox is a peptide-drug conjugate designed for targeted anticancer therapy. This prodrug demonstrates significant cytotoxic activity against triple-negative breast cancer (TNBC) cell lines, with IC50 values ranging from 311 nM to 34.25 μM for E0771, MDA-MB-231, and MDA-MB-468, as well as exhibiting effects on colorectal carcinoma (CrC) cells (LS 174T) and normal epithelial cells. Its unique mechanism allows for selective delivery of doxorubicin, making it a valuable tool for research applications focused on improving chemotherapy efficacy and reducing off-target effects in cancer treatment. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
