Product Data Sheet
APTO-253 hydrochloride
Catalog No. A53696
APTO-253 hydrochloride is a small molecule c-Myc inhibitor that stabilizes G-quadruplex DNA, leading to cell cycle arrest and apoptosis in acute myeloid leukemia cells. This compound exerts its anticancer effects through the induction of the tumor suppressor Kruppel-like factor 4 (KLF4). Additionally, APTO-253 hydrochloride has demonstrated antiarthritic activity, contributing to its potential application in various cancer and inflammatory disease research studies.
Chemical Information
| Catalog Num | A53696 |
|---|---|
| M. Wt | 367.38 |
| Formula | C22H14FN5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1691221-67-6 |
| Synonyms | LOR-253 hydrochloride; LT-253 hydrochloride |
| SMILES | CC(NC1=C2C=C(F)C=C1)=C2C3=NC4=C5C=CC=NC5=C6N=CC=CC6=C4N3 |
Biological Activity
| Description | APTO-253 hydrochloride is a small molecule c-Myc inhibitor that stabilizes G-quadruplex DNA, leading to cell cycle arrest and apoptosis in acute myeloid leukemia cells. This compound exerts its anticancer effects through the induction of the tumor suppressor Kruppel-like factor 4 (KLF4). Additionally, APTO-253 hydrochloride has demonstrated antiarthritic activity, contributing to its potential application in various cancer and inflammatory disease research studies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
