Product Data Sheet
Hexadecanedioic acid-d28
Catalog No. A53755
Hexadecanedioic acid-d28 is a stable isotope-labeled version of hexadecanedioic acid, which is known to be an orally active metabolite from Bacteroides uniformis. This compound functions as an inhibitor of the IRE1α-XBP1s pathway, effectively modulating flipogenesis and ferroptosis. Hexadecanedioic acid-d28 downregulates key targets, including XBP1 and Hrd1, while activating the Nrf2/SLC7A11/GPX4 pathway. It serves as a valuable tool for investigating mechanisms underlying metabolic-associated fatty liver disease and related metabolic disorders.
Chemical Information
| Catalog Num | A53755 |
|---|---|
| M. Wt | 314.58 |
| Formula | C16H2D28O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 130348-90-2 |
| Synonyms | |
| SMILES | O=C(O)C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C(O)=O |
Biological Activity
| Description | Hexadecanedioic acid-d28 is a stable isotope-labeled version of hexadecanedioic acid, which is known to be an orally active metabolite from Bacteroides uniformis. This compound functions as an inhibitor of the IRE1α-XBP1s pathway, effectively modulating flipogenesis and ferroptosis. Hexadecanedioic acid-d28 downregulates key targets, including XBP1 and Hrd1, while activating the Nrf2/SLC7A11/GPX4 pathway. It serves as a valuable tool for investigating mechanisms underlying metabolic-associated fatty liver disease and related metabolic disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
