Product Data Sheet
NSC 66811
Catalog No. A53826
NSC 66811 is a potent p53 activator that functions by inhibiting the interaction between MDM2 and p53, exhibiting a Ki of 120 nM for MDM2 binding. This compound reactivates p53, promoting its tumor suppressive functions, making it valuable for research in cancer biology, particularly in studies focused on MDM2-related pathways and p53 restoration. NSC 66811 is an essential tool for exploring therapeutic strategies aimed at overcoming MDM2-mediated p53 degradation in various malignancies.
Chemical Information
| Catalog Num | A53826 |
|---|---|
| M. Wt | 340.42 |
| Formula | C23H20N2O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 6964-62-1 |
| Synonyms | |
| SMILES | OC1=C2N=C(C)C=CC2=CC=C1C(C3=CC=CC=C3)NC4=CC=CC=C4 |
Biological Activity
| Description | NSC 66811 is a potent p53 activator that functions by inhibiting the interaction between MDM2 and p53, exhibiting a Ki of 120 nM for MDM2 binding. This compound reactivates p53, promoting its tumor suppressive functions, making it valuable for research in cancer biology, particularly in studies focused on MDM2-related pathways and p53 restoration. NSC 66811 is an essential tool for exploring therapeutic strategies aimed at overcoming MDM2-mediated p53 degradation in various malignancies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
