Product Data Sheet
p53 Activator 5
Catalog No. A53828
p53 Activator 5 (compound 134A) is a robust activator of the p53 tumor suppressor protein, exhibiting a SC150 value of <0.05 mM. This compound effectively binds to mutant forms of p53, restoring their DNA-binding capability and demonstrating significant anti-tumor activity. Additionally, p53 Activator 5 serves as a click chemistry reagent, featuring an alkyne group that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating various research applications in molecular biology and cancer therapeutics.
Chemical Information
| Catalog Num | A53828 |
|---|---|
| M. Wt | 566.58 |
| Formula | C29H32F6N4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2636840-37-2 |
| Synonyms | |
| SMILES | COC1=CC(C(F)(F)F)=CC=C1NCC#CC2=CC3=C(C=CC=C3N[C@@H](CC4)CC[C@H]4N(C)C)N2CC(F)(F)F |
Biological Activity
| Description | p53 Activator 5 (compound 134A) is a robust activator of the p53 tumor suppressor protein, exhibiting a SC150 value of <0.05 mM. This compound effectively binds to mutant forms of p53, restoring their DNA-binding capability and demonstrating significant anti-tumor activity. Additionally, p53 Activator 5 serves as a click chemistry reagent, featuring an alkyne group that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating various research applications in molecular biology and cancer therapeutics. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
