Product Data Sheet
ZMC2
Catalog No. A53848
ZMC2 is a thiosemicarbazone-class metal ion chelator and zinc ionophore that specifically targets the mutant p53 protein (R175H) with a binding affinity (Ka) of 27.4 nM. This compound effectively facilitates the transport of zinc ions across cellular membranes and restores zinc binding to zinc-deficient p53 mutants, which can reinstate the wild-type structure and function necessary for site-specific DNA binding. Additionally, ZMC2 generates reactive oxygen species (ROS), making it a valuable tool for cancer research applications.
Chemical Information
| Catalog Num | A53848 |
|---|---|
| M. Wt | 222.31 |
| Formula | C10H14N4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 71555-14-1 |
| Synonyms | |
| SMILES | S=C(NN=C(C1=NC=CC=C1)C)N(C)C |
Biological Activity
| Description | ZMC2 is a thiosemicarbazone-class metal ion chelator and zinc ionophore that specifically targets the mutant p53 protein (R175H) with a binding affinity (Ka) of 27.4 nM. This compound effectively facilitates the transport of zinc ions across cellular membranes and restores zinc binding to zinc-deficient p53 mutants, which can reinstate the wild-type structure and function necessary for site-specific DNA binding. Additionally, ZMC2 generates reactive oxygen species (ROS), making it a valuable tool for cancer research applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
