Product Data Sheet
Kevetrin
Catalog No. A53853
Kevetrin (3-Cyanopropyl carbamimidothioate; 4-Isothioureidobutyronitrile) is an apoptosis inducer that functions through both p53-dependent and p53-independent mechanisms. It activates and stabilizes the p53 protein in TP53 wild-type models by modulating MDM2 processing, leading to cell cycle arrest and apoptosis. Additionally, Kevetrin demonstrates enhanced efficacy in models with mutated TP53. This compound is valuable for research applications in various cancers, including acute myeloid leukemia and breast cancer.
Chemical Information
| Catalog Num | A53853 |
|---|---|
| M. Wt | 143.21 |
| Formula | C5H9N3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 500863-50-3 |
| Synonyms | 3-Cyanopropyl carbamimidothioate; 4-Isothioureidobutyronitrile |
| SMILES | N#CCCCSC(=N)N |
Biological Activity
| Description | Kevetrin (3-Cyanopropyl carbamimidothioate; 4-Isothioureidobutyronitrile) is an apoptosis inducer that functions through both p53-dependent and p53-independent mechanisms. It activates and stabilizes the p53 protein in TP53 wild-type models by modulating MDM2 processing, leading to cell cycle arrest and apoptosis. Additionally, Kevetrin demonstrates enhanced efficacy in models with mutated TP53. This compound is valuable for research applications in various cancers, including acute myeloid leukemia and breast cancer. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
