Product Data Sheet
USP7-IN-18
Catalog No. A53856
USP7-IN-18 is a selective inhibitor of Ubiquitin-specific protease 7 (USP7), demonstrating an IC50 of 130.9 nM with minimal inhibition on other deubiquitinases. By binding to the catalytic domain, USP7-IN-18 effectively blocks USP7's deubiquitinase activity, leading to the degradation of oncogenic proteins such as MDM2, DNMT1, and the novel target PCLAF. This compound activates the p53-p21 pathway and demonstrates potent anti-tumor effects in colon cancer models, while also modulating the tumor immune microenvironment through both direct and immune-synergistic mechanisms.
Chemical Information
| Catalog Num | A53856 |
|---|---|
| M. Wt | 546.08 |
| Formula | C30H28ClN3O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3052223-40-9 |
| Synonyms | |
| SMILES | CC1(C2C(N(C(C21)=O)CC3=CC4=C(C(C5=CC(Cl)=C6C=CC=CC6=C5OC7CCNCC7)=CC=N4)S3)=O)C |
Biological Activity
| Description | USP7-IN-18 is a selective inhibitor of Ubiquitin-specific protease 7 (USP7), demonstrating an IC50 of 130.9 nM with minimal inhibition on other deubiquitinases. By binding to the catalytic domain, USP7-IN-18 effectively blocks USP7's deubiquitinase activity, leading to the degradation of oncogenic proteins such as MDM2, DNMT1, and the novel target PCLAF. This compound activates the p53-p21 pathway and demonstrates potent anti-tumor effects in colon cancer models, while also modulating the tumor immune microenvironment through both direct and immune-synergistic mechanisms. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
