Product Data Sheet
p53 Activator 15
Catalog No. A53870
p53 Activator 15 is a novel p53 Y220C activator that functions by enhancing the DNA binding affinity of the mutated p53 protein, with a SC50 value of 0.58 nM. This compound demonstrates significant antiproliferative effects on NUGC-3 gastric cancer cells and effectively inhibits tumor growth in NUGC-3 xenograft models in both mouse and rat systems. p53 Activator 15 serves as a valuable tool for investigating the role of p53 activation in gastric cancer research.
Chemical Information
| Catalog Num | A53870 |
|---|---|
| M. Wt | 613.64 |
| Formula | C27H27D3F4N6O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3069395-29-2 |
| Synonyms | |
| SMILES | O=C(NS(C)(=O)=O)C1=CC=C(NCC#CC2=C(N3C=CC=C(C3=C2)N[C@@H]4CCN(C[C@@H]4F)C)CC(F)(F)F)C(OC([2H])([2H])[2H])=N1 |
Biological Activity
| Description | p53 Activator 15 is a novel p53 Y220C activator that functions by enhancing the DNA binding affinity of the mutated p53 protein, with a SC50 value of 0.58 nM. This compound demonstrates significant antiproliferative effects on NUGC-3 gastric cancer cells and effectively inhibits tumor growth in NUGC-3 xenograft models in both mouse and rat systems. p53 Activator 15 serves as a valuable tool for investigating the role of p53 activation in gastric cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
