Product Data Sheet
p53 (17-26)
Catalog No. A53871
p53 (17-26) is a peptide derived from the MDM2 binding domain of the tumor suppressor p53, with a binding affinity (Kd) of 50 nM for MDM2. This peptide demonstrates significant biological activity by inducing necrosis in cancer cells through disruption of cellular integrity and nuclear membrane damage. Research applications for p53 (17-26) include studies focused on pancreatic cancer and the development of therapeutic strategies targeting MDM2-mediated pathways.
Chemical Information
| Catalog Num | A53871 |
|---|---|
| M. Wt | 1251.43 |
| Formula | C60H90N12O17 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 488118-64-5 |
| Synonyms | |
| SMILES | C([C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CC(C)C)=O)CCCCN)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@H](CCC(O)=O)N)=O)[C@@H](C)O)=O)=O)CO)=O)CC(O)=O)=O)CC(C)C)=O)C=2C=3C(NC2)=CC=CC3 |
Biological Activity
| Description | p53 (17-26) is a peptide derived from the MDM2 binding domain of the tumor suppressor p53, with a binding affinity (Kd) of 50 nM for MDM2. This peptide demonstrates significant biological activity by inducing necrosis in cancer cells through disruption of cellular integrity and nuclear membrane damage. Research applications for p53 (17-26) include studies focused on pancreatic cancer and the development of therapeutic strategies targeting MDM2-mediated pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
