Product Data Sheet
NU-8165
Catalog No. A53883
NU-8165 is a potent inhibitor of the MDM2-p53 protein-protein interaction, exhibiting notable anti-tumor activity. Designed based on NMR titration insights to identify critical binding regions, NU-8165 effectively activates MDM2 and p21 transcription in cellular assays. This compound shows preferential effects in wild-type p53 cell lines, making it a valuable tool for studying p53 signaling and therapeutic applications in cancer research.
Chemical Information
| Catalog Num | A53883 |
|---|---|
| M. Wt | 407.89 |
| Formula | C24H22ClNO3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 849723-20-2 |
| Synonyms | |
| SMILES | O=C1N(CC2=CC=CC=C2)C(OCCCO)(C3=CC=C(Cl)C=C3)C4=C1C=CC=C4 |
Biological Activity
| Description | NU-8165 is a potent inhibitor of the MDM2-p53 protein-protein interaction, exhibiting notable anti-tumor activity. Designed based on NMR titration insights to identify critical binding regions, NU-8165 effectively activates MDM2 and p21 transcription in cellular assays. This compound shows preferential effects in wild-type p53 cell lines, making it a valuable tool for studying p53 signaling and therapeutic applications in cancer research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
