Product Data Sheet
Rhodojaponin VI
Catalog No. A53909
Rhodojaponin VI is a diterpenoid compound that primarily targets the N-Ethylmaleimide-sensitive fusion protein (NSF). It exhibits significant biological activity by blocking the MDM2-Notch1 signaling pathway, thereby reducing the expression of MDM2 and Notch1, and inhibits NSF-mediated Cav2.2 trafficking, leading to decreased Cav2.2 current intensity. Rhodojaponin VI demonstrates therapeutic potential in alleviating glomerulonephritis progression and protecting against podocyte injury in passive Heymann nephritis models. Additionally, it possesses antinociceptive properties, making it a valuable reagent for research in nephritis and pain mechanisms.
Chemical Information
| Catalog Num | A53909 |
|---|---|
| M. Wt | 386.48 |
| Formula | C20H34O7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 37720-87-9 |
| Synonyms | |
| SMILES | OC1[C@@]23[C@](CC[C@@]1([H])[C@](O)(C3)C)([H])[C@@](O)([C@@]4([H])[C@]([C@@H](C2)O)(C(C)([C@H]([C@@H]4O)O)C)O)C |
Biological Activity
| Description | Rhodojaponin VI is a diterpenoid compound that primarily targets the N-Ethylmaleimide-sensitive fusion protein (NSF). It exhibits significant biological activity by blocking the MDM2-Notch1 signaling pathway, thereby reducing the expression of MDM2 and Notch1, and inhibits NSF-mediated Cav2.2 trafficking, leading to decreased Cav2.2 current intensity. Rhodojaponin VI demonstrates therapeutic potential in alleviating glomerulonephritis progression and protecting against podocyte injury in passive Heymann nephritis models. Additionally, it possesses antinociceptive properties, making it a valuable reagent for research in nephritis and pain mechanisms. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
