Product Data Sheet
RO5353
Catalog No. A53915
RO5353 is an orally active MDM2 inhibitor that effectively disrupts the p53-MDM2 interaction, with an IC50 of 7 nM for MDM2. It demonstrates potent inhibitory effects on the proliferation of wild-type p53 cancer cells, achieving an average IC50 of 7 nM. In vivo studies reveal that RO5353 possesses significant antitumor efficacy and favorable pharmacokinetic properties in murine models, making it a valuable tool for cancer research focused on p53 pathway modulation.
Chemical Information
| Catalog Num | A53915 |
|---|---|
| M. Wt | 619.53 |
| Formula | C29H29Cl2FN4O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1360821-61-9 |
| Synonyms | |
| SMILES | NC(C1=CC(OC)=C(NC([C@H]2[C@H](C3=C(F)C(Cl)=CC=C3)[C@@]4(C(SC(Cl)=C5)=C5NC4=O)[C@H](CC(C)(C)C)N2)=O)C=C1)=O |
Biological Activity
| Description | RO5353 is an orally active MDM2 inhibitor that effectively disrupts the p53-MDM2 interaction, with an IC50 of 7 nM for MDM2. It demonstrates potent inhibitory effects on the proliferation of wild-type p53 cancer cells, achieving an average IC50 of 7 nM. In vivo studies reveal that RO5353 possesses significant antitumor efficacy and favorable pharmacokinetic properties in murine models, making it a valuable tool for cancer research focused on p53 pathway modulation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
