Product Data Sheet
Doxorubicinone
Catalog No. A54014
Doxorubicinone is the aglycone form of the anthracycline antibiotic Doxorubicin, functioning primarily as a Doxorubicin glycoside ligand. It exhibits notable anti-inflammatory activity by downregulating the expression of pro-inflammatory cytokines, including TNF and IL-12, through modulation of the NF-κB signaling pathway. Doxorubicinone is particularly useful in research related to sepsis and other inflammatory conditions, providing insights into cytokine regulation without inducing DNA damage.
Chemical Information
| Catalog Num | A54014 |
|---|---|
| M. Wt | 414.36 |
| Formula | C21H18O9 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 24385-10-2 |
| Synonyms | Adriamycin aglycone; Adriamycinone |
| SMILES | OC1=C(C2=C(C(C3=O)=C1C(C4=CC=CC(OC)=C34)=O)O)C[C@](O)(C[C@@H]2O)C(CO)=O |
Biological Activity
| Description | Doxorubicinone is the aglycone form of the anthracycline antibiotic Doxorubicin, functioning primarily as a Doxorubicin glycoside ligand. It exhibits notable anti-inflammatory activity by downregulating the expression of pro-inflammatory cytokines, including TNF and IL-12, through modulation of the NF-κB signaling pathway. Doxorubicinone is particularly useful in research related to sepsis and other inflammatory conditions, providing insights into cytokine regulation without inducing DNA damage. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
