Product Data Sheet
Ribociclib-d8
Catalog No. A54204
Ribociclib-d8 is a deuterated form of Ribociclib, a selective inhibitor of CDK4 and CDK6. It demonstrates potent inhibitory activity with IC50 values of 10 nM for CDK4 and 39 nM for CDK6, while exhibiting over a 1,000-fold reduced potency against the cyclin B/CDK1 complex. This stable isotope-labeled compound is ideal for applications in pharmacokinetic studies, drug metabolism research, and metabolic profiling.
Chemical Information
| Catalog Num | A54204 |
|---|---|
| M. Wt | 442.59 |
| Formula | C23H22D8N8O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2167898-24-8 |
| Synonyms | LEE011-d8 |
| SMILES | CN(C)C(C(N(C1CCCC1)C2=N3)=CC2=CN=C3NC4=CC=C(N5C([2H])([2H])C([2H])([2H])NC([2H])([2H])C5([2H])[2H])C=N4)=O |
Biological Activity
| Description | Ribociclib-d8 is a deuterated form of Ribociclib, a selective inhibitor of CDK4 and CDK6. It demonstrates potent inhibitory activity with IC50 values of 10 nM for CDK4 and 39 nM for CDK6, while exhibiting over a 1,000-fold reduced potency against the cyclin B/CDK1 complex. This stable isotope-labeled compound is ideal for applications in pharmacokinetic studies, drug metabolism research, and metabolic profiling. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
