Product Data Sheet
PNU-292137
Catalog No. A54214
PNU-292137 is a potent inhibitor of Cyclin-Dependent Kinase 2 (CDK2), with IC50 values of 37 nM for the CDK2/cyclin A complex and 92 nM for the CDK2/cyclin E complex. This compound interacts with the hydrophobic pocket located within the ATP binding site of CDK2, effectively hindering tumor cell proliferation in human colon and prostate cancer cell lines. Additionally, PNU-292137 demonstrates significant antitumor activity in vivo, evidenced by a tumor growth inhibition greater than 50% in mouse xenograft models, making it a valuable tool for cancer research.
Chemical Information
| Catalog Num | A54214 |
|---|---|
| M. Wt | 291.35 |
| Formula | C18H17N3O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 326823-27-2 |
| Synonyms | |
| SMILES | O=C(CC1=CC=C2C=CC=CC2=C1)NC3=NNC(C4CC4)=C3 |
Biological Activity
| Description | PNU-292137 is a potent inhibitor of Cyclin-Dependent Kinase 2 (CDK2), with IC50 values of 37 nM for the CDK2/cyclin A complex and 92 nM for the CDK2/cyclin E complex. This compound interacts with the hydrophobic pocket located within the ATP binding site of CDK2, effectively hindering tumor cell proliferation in human colon and prostate cancer cell lines. Additionally, PNU-292137 demonstrates significant antitumor activity in vivo, evidenced by a tumor growth inhibition greater than 50% in mouse xenograft models, making it a valuable tool for cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
