Product Data Sheet
Ribociclib-d6
Catalog No. A54223
Ribociclib-d6 is a deuterium-labeled derivative of Ribociclib, a highly selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). It exhibits potent inhibitory activity with IC50 values of 10 nM and 39 nM for CDK4 and CDK6, respectively, while demonstrating over 1,000-fold reduced potency against the cyclin B/CDK1 complex. Ribociclib-d6 serves as a valuable tool for studying CDK4/6 dynamics and evaluating the pharmacokinetics of Ribociclib in chemical biology research and therapeutic applications in cancer treatment.
Chemical Information
| Catalog Num | A54223 |
|---|---|
| M. Wt | 440.57 |
| Formula | C23H24D6N8O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1328934-40-2 |
| Synonyms | LEE011-d6 |
| SMILES | O=C(C1=CC2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5)N(C([2H])([2H])[2H])C([2H])([2H])[2H] |
Biological Activity
| Description | Ribociclib-d6 is a deuterium-labeled derivative of Ribociclib, a highly selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). It exhibits potent inhibitory activity with IC50 values of 10 nM and 39 nM for CDK4 and CDK6, respectively, while demonstrating over 1,000-fold reduced potency against the cyclin B/CDK1 complex. Ribociclib-d6 serves as a valuable tool for studying CDK4/6 dynamics and evaluating the pharmacokinetics of Ribociclib in chemical biology research and therapeutic applications in cancer treatment. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
