Product Data Sheet
[Ala92]-p16 (84-103)
Catalog No. A54259
[Ala92]-p16 (84-103) is a peptide derived from the p16CDKN2/INK4a tumor suppressor protein that targets CDK4-Cyclin D1 kinase. This peptide effectively binds to CDK4 and CDK6, demonstrating an inhibitory effect on CDK4-cyclin D1 activity with an IC50 of 1.5 μM. Its mechanism of action leads to the blockade of cell cycle progression through the G1 phase, making it a valuable reagent for cancer research and studies focusing on cell cycle regulation.
Chemical Information
| Catalog Num | A54259 |
|---|---|
| M. Wt | 2123.42 |
| Formula | C93H155N31O26 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 189064-08-2 |
| Synonyms | |
| SMILES | [C@H](CC1=CN=CN1)(C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)C)=O)=O)C)=O)CCCNC(=N)N)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(O)=O)N)=O)C)=O)C)=O)CCCNC(=N)N)=O)CCC(O)=O)=O)=O)=O)CC(C)C)=O)C)=O)[C@@H](C)O)=O)CC(C)C)=O)C(C)C)=O)C(C)C)=O)CC(C)C)=O |
Biological Activity
| Description | [Ala92]-p16 (84-103) is a peptide derived from the p16CDKN2/INK4a tumor suppressor protein that targets CDK4-Cyclin D1 kinase. This peptide effectively binds to CDK4 and CDK6, demonstrating an inhibitory effect on CDK4-cyclin D1 activity with an IC50 of 1.5 μM. Its mechanism of action leads to the blockade of cell cycle progression through the G1 phase, making it a valuable reagent for cancer research and studies focusing on cell cycle regulation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
