Product Data Sheet
CDK4-IN-1
Catalog No. A54270
CDK4-IN-1 is a selective inhibitor of Cyclin-dependent kinase 4 (CDK4), exhibiting an IC50 of 10 nM. This compound demonstrates significant specificity, being 1500-fold and 500-fold less potent against CDK1/Cyclin B and CDK2/Cyclin A, respectively, with IC50 values greater than 15 µM and 5 µM. CDK4-IN-1 is primarily utilized in research focused on cell cycle regulation and anti-cancer therapies, particularly in the context of cancers characterized by aberrant CDK4 activity.
Chemical Information
| Catalog Num | A54270 |
|---|---|
| M. Wt | 440.97 |
| Formula | C22H29ClN8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1256963-02-6 |
| Synonyms | |
| SMILES | CN(C1CCN(C2=CN=C(NC3=NC=CC(C4=C(Cl)NN=C4C(C)C)=N3)C=C2)CC1)C |
Biological Activity
| Description | CDK4-IN-1 is a selective inhibitor of Cyclin-dependent kinase 4 (CDK4), exhibiting an IC50 of 10 nM. This compound demonstrates significant specificity, being 1500-fold and 500-fold less potent against CDK1/Cyclin B and CDK2/Cyclin A, respectively, with IC50 values greater than 15 µM and 5 µM. CDK4-IN-1 is primarily utilized in research focused on cell cycle regulation and anti-cancer therapies, particularly in the context of cancers characterized by aberrant CDK4 activity. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
