Product Data Sheet
GDC-4198
Catalog No. A54277
GDC-4198 is an orally active inhibitor of cyclin-dependent kinases 4 and 2 (CDK4/2), exhibiting selective activity against kinases such as CDK6, CDK9, and GSK3β. By inhibiting cyclin-CDK complexes, GDC-4198 effectively blocks the phosphorylation of retinoblastoma protein (pRb), thus halting the cell cycle progression from the G1 to S phase. This compound is a valuable tool for investigating various cancers, particularly breast cancer (especially hormone receptor-positive, HER2-negative), lung cancer, and colorectal cancer.
Chemical Information
| Catalog Num | A54277 |
|---|---|
| M. Wt | 470.57 |
| Formula | C26H30N8O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2531743-46-9 |
| Synonyms | RGT-419B |
| SMILES | CC(C1=C2N(N=C1)C=CC(C3=NC(NC4=CC=C(N5C(C[C@H](CC5)N(C)C)=O)C=N4)=NC=C3)=C2)C |
Biological Activity
| Description | GDC-4198 is an orally active inhibitor of cyclin-dependent kinases 4 and 2 (CDK4/2), exhibiting selective activity against kinases such as CDK6, CDK9, and GSK3β. By inhibiting cyclin-CDK complexes, GDC-4198 effectively blocks the phosphorylation of retinoblastoma protein (pRb), thus halting the cell cycle progression from the G1 to S phase. This compound is a valuable tool for investigating various cancers, particularly breast cancer (especially hormone receptor-positive, HER2-negative), lung cancer, and colorectal cancer. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
